巴西专利BR112013024788B1 liquid drug transfer assembly

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专利摘要:
NET DRUG TRANSFER ASSEMBLY. The present invention relates to liquid drug transfer assemblies (100A) for use with a drug vial (20) having a drug vial opening (23) stopped by a drug vial closure (24). The liquid drug transfer assemblies (100A) include a puncture member for the closure of the drug vial (24). The liquid drug transfer assemblies (100A) also include a drug vial adapter (120) having a drug vial adapter skirt (122), a vertical drug vial adapter port (124) and a drug sleeve. drug vial adapter (131) downwardly opposite the vertical port of the drug vial adapter (124) and in fluid communication with it. The drug vial adapter (120) is slidably in the puncture member of the drug vial closure (110) so that in the assembly the liquid drug transfer assembly (100A) in the drug vial (20), the member of puncture closure of the drug vial (110) punctures the closure of the drug vial (24) to form a complete drilling hole P and the sleeve of the drug vial adapter (131) aligns with the puncture hole P.
公开号:BR112013024788B1
申请号:R112013024788-6
申请日:2012-04-17
公开日:2021-02-17
发明作者:Igor Denenburg；Nimrod Lev；Mordechai Bukhman
申请人:Medimop Medical Projects Ltd.；
IPC主号:

专利说明:

[0001] [0001] The present invention relates to liquid drug transfer assemblies for reconstitution of the liquid drug and purposes of administration. Background of the Invention
[0002] [0002] Linear transfer clamps of double lumen with double end are typically employed for gravitational transfer of liquid from an ampoule of liquid containing a liquid component to a drug ampoule containing a drug component to form the liquid drug contents in the ampoule of drug for purposes of administration and simultaneous air transfer from the drug vial to the liquid vial for pressure equalization. The transfer clamps expose the closure of the drug vial and the puncture member of the liquid vial closure with puncture tips of the sharp vial closure that pose a danger to users in general and home users in particular. In addition, it is difficult to precisely center and correctly insert a transfer clamp into an ampoule closure to ensure that the transfer clamp correctly perforates it for fluid communication with an interior of the ampoule. In addition, a user has to manually remove the transfer clamp and use other means, for example, a needle, to remove the liquid drug contents which can be a complicated action leading to a needle wound and contamination of the liquid drug contents . Summary of the Invention
[0003] [0003] The invention relates to liquid drug transfer assemblies for use with a drug vial including a drug vial bottle containing a drug component and having a drug vial opening stopped by a drug vial closure. The drug component is typically a powdered drug component, but it can also be a liquid drug component of different viscosities. The liquid drug transfer assemblies include a puncture member of the drug vial closure and a drug vial adapter having a substantially cylindrical drug vial adapter skirt with an upper surface of the drug vial adapter, a part of drug ampoule adapter body to telescope slidably receive an opening of the drug ampoule in it and a skirt edge of the drug ampoule adapter. The upper surface of the drug vial adapter is formed with a vertical drug vial adapter port and a dependent dependent drug vial adapter sleeve opposite the drug vial adapter port and in fluid communication with it. The drug vial adapter skirt can optionally be formed from a wide variety of at least two flexing members of the drug vial adapter. The drug vial adapter skirt can optionally include protrusions directed inwardly to snap into an opening of the drug vial. The skirt edge of the drug vial adapter can optionally be externally enlarged with respect to the body part of the drug vial adapter to assist in guiding the drug vial adapter into a drug vial. The drug vial adapter is slidably arranged on the drug vial closure puncture member so that its drug vial closure puncture member projects beyond the drug vial adapter sleeve into a configuration position of the drug assembly. liquid drug transfer.
[0004] [0004] The liquid drug transfer assembly is mounted in a drug vial so that the puncture member of the drug vial closure punctures the drug vial closure to form a complete perforation hole and the adapter sleeve of the drug vial. drug vial aligns with the puncture hole through the closure of the drug vial. The drug vial adapter sleeve for the closure of the drug vial is sealed upon withdrawal of the puncture member from the closure of the drug vial, thus maintaining continuous fluid communication between the drug vial bottle and the adapter port of the drug vial. The adapter sleeve of the drug vial also prevents debris from the closure of the drug vial that contaminates the contents of liquid drug in a drug vial. Suitable medical devices can be readily mounted on the drug vial adapter port for fluid communication with the drug vial bottle. Suitable medical devices include, among others, a needle-free syringe, an administration line, and the like.
[0005] [0005] The puncture member of the drug vial closure can be configured as one end of a double lumen linear transfer clamp with double end including an opposite puncture member of the liquid vial closure to pierce a vial closure. liquid from an ampoule of liquid containing a liquid component. The liquid component is typically a diluent, but it can also contain an active drug component. Such a double lumen linear transfer clamp with double end allows simultaneous gravitational liquid transfer from a liquid vial to a drug vial to form the liquid drug contents in a drug vial for the purpose of administration and air transfer of the vial drug to liquid ampoule for pressure equalization purposes.
[0006] [0006] The linear transfer clip of the double lumen with double end can be integrally formed with a liquid ampoule adapter to mount in a liquid ampoule. Alternatively, the double-ended double lumen linear transfer clamp can be integrally formed with a liquid drug transfer device for use with a discrete liquid ampule adapter to mount in a liquid ampoule thus forming a transfer assembly of triple component liquid drug including the drug vial adapter. The liquid drug transfer device includes a directionally spaced ring transversely midway between the double lumen double transfer linear clamp, at least two longitudinally directed drug ampoule legs and at least two directed liquid ampoule legs. longitudinally opposite to at least the two longitudinally directed legs of the drug vial. The legs of the drug vial and the legs of the liquid vial are used to centralize the purposes of its puncture tip of the corresponding drug vial closure and the puncture tip of the liquid vial closure with respect to their respective vial closures. Brief Description of Drawings
[0007] [0007] In order to understand the invention and see how it can be carried out in practice, the preferred embodiments will now be described, in the form of non-limiting examples only, with reference to the accompanying drawings in which similar parts are numbered in a similar manner, and in which:
[0008] [0008] Fig. 1 is a graphical representation of a first preferred embodiment of a liquid drug transfer assembly including a puncture member of the drug vial closure and a drug vial adapter, a blister pack for long-term storage. term, a needle-free syringe and a drug vial;
[0009] [0009] Fig. 2 is an enlarged view of the liquid drug transfer assembly of Figure 1;
[0010] [00010] Fig. 3 is a longitudinal cross-section of the liquid drug transfer assembly of Figure 1 in its initial state ready for use by line A-A in Figure 1;
[0011] [00011] Fig. 4A is a longitudinal cross-section of the liquid drug transfer assembly of Figure 1 in a configuration position and arranged coaxially with the drug vial ready to fit by pressure;
[0012] [00012] Fig. 4B is a longitudinal cross-section of the liquid drug transfer assembly of Figure 1 according to an initial depression downwards towards the drug vial;
[0013] [00013] Fig. 4C is a longitudinal cross-section of the liquid drug transfer assembly of Figure 1 according to the complete pressure fitting of the drug vial adapter in the drug vial;
[0014] [00014] Fig. 4D is a longitudinal cross-section of the liquid drug transfer assembly of Figure 1 according to the removal of the puncture member from the closure of the drug vial;
[0015] [00015] Fig. 5 is a longitudinal cross-section of an alternative embodiment of the liquid drug transfer assembly of Figure 1 including a puncture member of the drug vial closure having a liquid drug access port and an in-line filter. ;
[0016] [00016] Fig. 6 is a longitudinal cross-section of another alternative embodiment of the drug vial adapter of Figure 1 including a component of the drug vial adapter sleeve mounted on its upper surface of the drug vial adapter;
[0017] [00017] Fig. 7 is a graphical representation of a second preferred embodiment of a liquid drug transfer assembly including a liquid vial adapter and a drug vial adapter, a blister pack for long-term storage thereof, a needle-free syringe, a drug vial, and a liquid vial;
[0018] [00018] Fig. 8 is an enlarged view of the liquid drug transfer assembly of Figure 7;
[0019] [00019] Fig. 9 is a longitudinal cross-section of the liquid drug transfer assembly of Figure 7 in its initial state ready for use by line B-B in Figure 7;
[0020] [00020] Fig. 10A shows the liquid drug transfer assembly of Figure 7 coaxial with a drug vial ready to snap into it;
[0021] [00021] Fig. 10B shows the liquid drug transfer assembly of Figure 7 snapped into the drug vial;
[0022] [00022] Fig. 10C shows the inversion of the assembly of Figure 10B ready for fitting by pressure in the liquid ampoule;
[0023] [00023] Fig. 10D shows the assembly of Figure 10B fitted by pressure in the liquid ampoule;
[0024] [00024] Fig. 10E shows the assembly of Figure 10D in an inverted position to allow the transfer of gravitational liquid from the liquid vial to the drug vial to form liquid drug contents in the drug vial and venting from the drug vial to the vial of liquid;
[0025] [00025] Fig. 10F shows the drug vial adapter mounted on the drug vial containing liquid drug contents after removal of the liquid drug vial with its liquid vial stuck empty; and
[0026] [00026] Fig. 10G shows the use of the needle-free syringe to aspirate the liquid drug contents from the drug vial for administration purposes;
[0027] [00027] Fig. 11 is a graphical representation of a third preferred embodiment of a liquid drug transfer assembly including a liquid drug transfer device, a drug vial adapter, and a liquid vial adapter in its state. ready-to-use initial, a blister pack for long-term storage, a needle-free syringe, a drug vial, and a liquid vial;
[0028] [00028] Fig. 12 is a perspective view of the liquid drug transfer assembly of Figure 11;
[0029] [00029] Fig. 13 is an enlarged view of the liquid drug transfer assembly of Figure 11 and an enlarged cross section of the linear double-lumen transfer clamp with double end of the liquid drug transfer device;
[0030] [00030] Fig. 14 is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 in its initial state ready for use by line C-C in Figure 11;
[0031] [00031] Fig. 15A is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 coaxial with the drug vial ready to snap into it;
[0032] [00032] Fig. 15B is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 according to an initial depression below the liquid drug transfer assembly towards the drug vial;
[0033] [00033] Fig. 15C is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 according to another depression below the liquid drug transfer assembly towards the drug vial;
[0034] [00034] Fig. 15D is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 according to another depression down the liquid drug transfer assembly towards the drug vial;
[0035] [00035] Fig. 15E is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 according to complete pressure fitting of the drug vial adapter into the drug vial;
[0036] [00036] Fig. 15F is a longitudinal cross-section of the liquid drug transfer assembly of Figure 11 showing the complete press fit of the drug vial and the liquid vial including pressure coupling of the liquid drug transfer device and the liquid ampoule adapter;
[0037] [00037] Fig. 16A shows the coaxial liquid drug transfer assembly of Figure 11 with a drug vial ready to snap into it;
[0038] [00038] Fig. 16B shows the liquid drug transfer assembly of Figure 11 snapped into the drug vial;
[0039] [00039] Fig. 16C shows the inversion of the assembly of Figure 16B ready for fitting by pressure in the liquid ampoule;
[0040] [00040] Fig. 16D shows the assembly of Figure 16B fitted by pressure in the liquid ampoule;
[0041] [00041] Fig. 16E shows the assembly of Figure 16D in an inverted position to allow the transfer of gravitational liquid from the liquid vial to the drug vial to form liquid drug contents in the drug vial and ventilation from the drug vial to the vial of liquid;
[0042] [00042] Fig. 16F shows the drug vial adapter mounted on the drug vial containing liquid drug contents after removing the liquid drug transfer device and the liquid drug adapter with its liquid vial attached empty; and
[0043] [00043] Fig. 16G shows the use of the needle-free syringe to draw liquid drug contents from the drug vial for administration purposes.
[0044] [00044] Detailed Description of the Preferred Modalities of the Invention
[0045] [00045] Figure 1 shows a liquid drug transfer assembly 100A for use with a needleless syringe 10 and a drug vial 20. Syringe 10 includes a barrel 11 with a plunger 12 and a male Luer lock connector 13. Syringe 10 can be formed with other types of male connectors. Syringe 10 is filled with a liquid component 14. The liquid component 14 can be diluent only. Alternatively, the liquid component 14 can include an active component. The drug vial 20 has a longitudinal axis of the drug vial 20A and includes a drug vial bottle 21 having a recess of the drug vial 22 and an opening of the drug vial 23 sealed by a closure of the drug vial 24. The opening of the drug vial 23 has a rim of the extreme upper drug vial 26. The drug vial 20 contains a drug component 27. The liquid drug transfer assembly 100A is preferably packaged in a blister pack 101A having an inner surface 102 and a protective seal 103.
[0046] [00046] Figures 1 to 3 show the liquid drug transfer assembly 100A which includes a puncture member of the drug vial closure 110 having a longitudinal axis of the puncture member of the drug vial closure 111 and a vial adapter drug pack 120. The blister pack 101A is formed and sized to comfortably fit the liquid drug transfer assembly 100A inside and used to mount it in the drug vial 20. The puncture member of the closure of the drug vial 110 has a tip for puncture the closure of the drug vial 112 to pierce the closure of the drug vial 24 and a transverse directed head 113.
[0047] [00047] The drug vial adapter 120 has a longitudinal axis of the drug vial adapter 121 and includes a drug vial adapter skirt 122 having the upper surface of the transversely directed drug vial adapter 123 formed with a vertical port of the drug ampoule adapter 124 and a wide variety of six downward dependent drug ampoule adapter flexing members 126. The flexing members of the drug ampoule adapter 126 are provided with internal directed protrusions 127 for snap fit into the opening of the drug ampoule 23 and define a body part of the drug ampoule adapter 128 to comfortably receive the opening of the drug ampoule 23. The flexing members of the drug ampoule 126 define a skirt edge of the ampoule adapter drug 129 externally enlarged with respect to the body part of the drug vial adapter 128 to assist in guiding the drug vial adapter 120 into the ampoule the drug 20. The adapter port of the drug vial 124 is preferably implemented as a female Luer connector for engaging the needle-free syringe thread 10 therein. Alternatively, the drug vial adapter port 124 can be formed with a large diameter, for example, to allow the gravitational flow of the viscous liquid drug contents of a drug vial 20.
[0048] [00048] The drug vial adapter 120 also includes a downward dependent drug vial adapter sleeve 131 opposite the drug vial adapter port 124 and in fluid communication with it. The drug vial adapter 120 including the drug vial adapter port 124 and the drug vial adapter sleeve 131 can be formed as a single molded plastic injection unit of the same suitable plastic material, for example, polycarbonate, and similar. The drug vial adapter adapter sleeve 131 for the drug vial closure clamp puncture tip 112 in an initial configuration position of the liquid drug transfer assembly 100A so that the drug vial closure clamp puncture tip 112 projects beyond. Thus, the puncture tip of the drug vial closure 112 contacts a drug vial closure 24 before the drug vial adapter sleeve 131 in the liquid drug transfer assembly 100A in the drug vial 20.
[0049] [00049] Figures 4A to 4D show the use of the liquid drug transfer assembly 100A for reconstitution of the liquid drug and administration as follows:
[0050] [00050] Figure 4A shows the liquid drug transfer assembly 100A in its initial ready-to-use state for snapping into the drug vial 20 by depressing downward from the previous 100A towards the last 20.
[0051] [00051] Figure 4B shows the initial depression downward of the liquid drug transfer assembly 100A towards the drug vial 20 simultaneously causing the skirt edge of the drug vial adapter 129 to align the drug vial adapter coaxially. 120 with the drug vial 20 and the puncture tip of the drug vial 112 closure to begin to pierce the closure of the drug vial 24.
[0052] [00052] Figure 4C shows complete pressure fitting of the liquid drug transfer assembly 100A into the drug vial 20 including complete penetration of the drug vial closure that penetrates the member 110 through the drug vial closure 24 to form a complete drilling hole P.
[0053] [00053] Figure 4D shows the removal of the closure of the drug vial that penetrates the member 110 of the drug vial 20 leaving the adapter of the drug vial 120 in place. The adapter sleeve of the drug vial 131 aligns with the puncture hole P to prevent the closure of the drug vial 24 from sealing. The drug vial adapter sleeve 131 also prevents any remainder of the drug vial closure from falling into the drug vial bottle to contaminate the contents of the vial. The needle-free syringe 10 can be readily mounted on the female Luer connector 124 to inject its contents into the drug ampoule bottle 21 for reconstitution or dilution purposes.
[0054] [00054] Figure 5 shows the liquid drug transfer assembly 100A including a drug puncture closure member 110 having a liquid drug access port 114 with a longitudinal lumen 116 to allow fluid communication access to the drug bottle. drug vial 21 in the perforation of the closure of drug vial 24. The liquid drug access port 114 can optionally be formed as a female Luer connector. The liquid drug access port 114 and / or longitudinal lumen 116 can optionally be formed with an in-line filter 117.
[0055] [00055] Figure 6 shows an alternative embodiment of the drug vial adapter 120 including a component of the drug vial adapter 133 mounted on its upper surface of the drug vial adapter 123. The component of the vial adapter sleeve of drug 133 may be formed from a different material than the rest of the drug ampoule adapter 120. Suitable materials include, among other materials, elastomer, metal, neoprene fabrics, rubber, silicone, glass, and the like.
[0056] [00056] Figure 7 shows a liquid drug transfer assembly 100B for use with an empty syringe 10, a drug vial 20 and a liquid vial 30. The liquid vial 30 has a longitudinal axis 30A and includes a bottle of liquid ampoule 31 having a recess of the liquid ampoule 32 and an opening of the liquid drug ampoule 33 stopped by a closure of the liquid ampoule 34. The opening of the liquid ampoule 33 has a rim of the extreme upper liquid ampoule 36. A liquid ampoule 30 contains a liquid component 37 to add to drug component 27. The liquid drug transfer assembly 100B is preferably packaged in a blister pack 101B formed and sized to comfortably fit the liquid drug transfer assembly 100B inside and employed for its operation.
[0057] [00057] Figures 7 to 9 show the liquid drug transfer assembly 100B that includes a drug vial adapter 120 and a liquid vial adapter 140. The liquid vial adapter 140 has a longitudinal axis of the vial adapter liquid 141 and includes a liquid vial adapter skirt 142 having a top surface of the transversely directed liquid vial adapter 143 formed with a wide variety of six flexing members of the downward dependent liquid vial adapter 144. The members flexing tips of the liquid ampoule 144 are provided with internal directed protrusions 146 for snap fit into the opening of the liquid ampoule 33 and define a part of the body of the liquid ampoule adapter 147 to comfortably receive the opening of the liquid ampoule 33 The flexing members of the liquid ampoule adapter 144 define an externally enlarged skirt edge of the liquid ampoule adapter 148 c with respect to the body part of the liquid ampoule adapter 147 to assist in guiding the liquid ampoule adapter 140 into the liquid ampoule 30.
[0058] [00058] The liquid ampoule adapter 140 also includes a double lumen double lumen linear transfer clip 151 having a drug ampoule closure puncture member 152 to pierce the drug ampoule closure 24 and an opposite member of puncture of the liquid ampoule closure 153 to puncture the closure of the ampoule of liquid 34. The puncture member of the closure of the drug ampoule 152 extends from the upper surface of the liquid ampoule adapter 143 away from the skirt of the liquid ampoule adapter 142. The drug vial closure puncture member 152 terminates at a drug vial closure closure puncture tip 154 that extends beyond the drug vial adapter sleeve 131 in the liquid drug vial adapter assembly 140 in the drug vial adapter 120. The liquid vial closure puncture member 153 extends from the top surface of the liquid vial adapter 143 to the skirt of the liquid vial adapter 142. The puncture member of the vial closure The liquid bead 153 ends at a puncture tip of the liquid ampoule closure 156. The double lumen linear transfer clamp 151 includes a liquid transfer lumen 157 for transferring liquid from the liquid ampoule 30 to the injection ampoule. drug 20 and an air transfer lumen 158 for transferring air from the drug 20 ampoule to the liquid 30 ampoule for pressure equalization purposes.
[0059] [00059] Figures 10A to 10G show the use of the liquid drug transfer assembly 100B for reconstitution of the liquid drug and administration as follows:
[0060] [00060] Figure 10A shows the liquid drug transfer assembly 100B in its initial ready-to-use state for snapping into the drug vial 20 by depressing downward from the previous 100 towards the last 20.
[0061] [00061] Figure 10B shows the complete pressure fitting of the liquid drug transfer assembly 100B including complete penetration of the closure of the drug vial that penetrates member 152 through the closure of the drug vial 24 to form a complete drilling hole P .
[0062] [00062] Figure 10C shows the inversion of the assembly of figure 10B ready for fitting by pressing the adapter of the liquid ampoule 140 into the liquid ampoule 30.
[0063] [00063] Figure 4D shows the complete pressure fitting of the liquid drug transfer assembly 100B including the drug vial 20 in the liquid vial 30.
[0064] [00064] Figure 10E shows the inversion of the assembly of Figure 10D to allow the transfer of gravitational liquid from the liquid vial 30 to the drug vial 20 to form LD liquid drug contents in the drug vial 20 and ventilation of the drug vial 20 to the liquid ampoule 30. A user can gently shake the inverted assembly of figure 10D to facilitate reconstitution or dilution depending on the drug component and the liquid component.
[0065] [00065] Figure 10F shows the removal of the liquid ampoule adapter 140 together with its empty trapped liquid ampoule 30 to leave the drug ampoule 20 with the LD liquid drug contents. The adapter sleeve of the drug vial 131 aligns with the puncture hole P to prevent the closure of the drug vial from sealing. The drug vial adapter sleeve 131 also prevents any remainder of the drug vial closure from falling into the drug vial bottle to contaminate the contents.
[0066] [00066] Figure 10G shows the use of needle-free syringe 10 to aspirate the LD liquid drug contents from the drug vial 20 for administration purposes.
[0067] [00067] Figures 11 to 14 show a liquid drug transfer assembly 100C for use with an empty syringe 10, a drug vial 20 and a liquid vial 30. The liquid drug transfer assembly 100C has a component construction triple including a drug vial adapter 160, a liquid vial adapter 170 and a liquid drug transfer device 180 having a longitudinal axis of the liquid drug transfer device 181. The liquid drug transfer assembly 100C is preferably packaged in a 101C honeycomb package formed and sized to comfortably fit the 100C liquid drug transfer assembly inside and used for its operation.
[0068] [00068] The drug vial adapter 160 has the same construction as the drug vial adapter 120 and thus similar parts are enumerated in a similar manner. The drug vial adapter 160 differs from the drug vial adapter 120 in that the former 160 includes an opposite pair of flexing members of the drug vial adapter 161 formed with through-through openings of the leg of the drug vial 162 in the region of the body part of the drug vial adapter 128. In addition, the flexing members of the drug vial adapter 161 have the flat outer surfaces 163 in the region of the skirt edge of the drug vial adapter 129 as opposed to the rough surfaces of the flexing members of the drug vial adapter 126.
[0069] [00069] The liquid ampoule adapter 170 has the same construction as the liquid ampoule adapter 140 and thus similar parts are enumerated in a similar way. The liquid ampoule adapter 170 differs from the liquid ampoule adapter 140 in that the former 170 includes an opposite pair of flexing members of the liquid ampoule adapter 171 formed with through-through openings of the leg of the liquid ampoule 172 in the body part region of the liquid ampoule adapter 147. In addition, the flexing members of the liquid vial adapter 171 have flat outer surfaces 173 in the region of the skirt edge of the liquid vial adapter 148 as opposed to the rough surfaces of the flexing members of the liquid drug vial adapter 144.
[0070] [00070] And in addition, the liquid ampoule adapter 170 is formed without the double lumen linear transfer clip with double end 151 and still has a vertical tubular member 174 extending from the upper surface of the liquid ampoule adapter 143 away from the exit the adapter of the liquid ampoule 142. The tubular member 174 includes a transversely directed flange 176.
[0071] [00071] The liquid drug transfer device 180 is similar in construction to the double lumen double end linear transfer clamp 151 and thus similar parts are enumerated in a similar manner. The liquid drug transfer device 180 includes a puncture member of the drug vial closure 152 that terminates at a puncture tip of the drug vial closure 154 and an opposite puncture member of the closure of the liquid vial 153 that terminates at a puncture tip of the liquid ampoule closure 156. The liquid drug transfer device 180 includes a liquid transfer lumen 157 and an air transfer lumen 158. The liquid transfer lumen 157 has a larger cross-sectional area than the lumen than the air transfer lumen 158. The liquid transfer lumen 157 has a generally increasing cross-section that partially surrounds the air transfer lumen 158 thus reducing the entire cross-sectional area of the transfer clamp to facilitate perforation of the drug and closures of the liquid ampoule 24 and 34.
[0072] [00072] The liquid drug transfer device 180 is additionally formed with a transverse directional spacing ring 182 rigidly mounted in half, a pair of longitudinally directed drug vial legs 183 hinged on the spacing ring 182 and extending codirectionally and far of the puncture member of the drug vial closure 152 and a pair of longitudinally directed liquid vial legs 184 hinged at the spacing ring 182 and extending co-directs and away from the puncture member of the closure of the liquid vial 153. The legs of the drug vial 183 terminate at the leg ends of the coextensive drug vial 186 and inwardly projecting toward the puncture tip of the drug vial 154 closure. The leg vials of the drug vial 186 are directed to be initially inserted into the openings passers-by 162. The legs of the liquid ampoule 184 end at the tips of the leg of the liquid ampoule 187 coextensive and inward p gyrating towards the puncture tip of the liquid ampoule closure 156. The tips of the leg of the liquid ampoule 187 are directed to be initially inserted into the through openings 172.
[0073] [00073] The legs of the liquid ampoule 184 are preferably formed with a pair of protrusions of the liquid ampoule leg directed outwardly 188 to support against the inner surface 102 of the blister pack 101C to assist in pressure fitting of the transfer transfer assembly. 100C liquid drug in drug vial 20.
[0074] [00074] The liquid drug transfer assembly 100C includes a pressure snap arrangement 190 for mechanically securing the adapter of the liquid ampoule 140 to the spacing ring 182 in the pressure fitting of the adapter of the liquid ampoule 140 in the liquid ampoule 30 The snap-fit arrangement 190 consists of the tubular member 174 and the spacing ring 182 having a pair of snap members 191 for snap-fit on the transversely directed flange 176.
[0075] [00075] Figures 15A to 15E show the operation of the liquid drug transfer assembly 100C for pressure fitting in the drug vial 20.
[0076] [00076] Figure 15A shows the coaxial liquid drug transfer assembly 100C with the drug vial 20 ready to snap into it.
[0077] [00077] Figure 15B shows an initial depression downward from the liquid drug transfer assembly 100C toward the drug vial 20. The tips of the leg of the drug vial 186 stimulate the skirt edge of the drug vial adapter 129 to coaxially align the drug vial adapter 120 with the drug vial 20 and the puncture tip of the drug vial closure 156 to begin puncturing the closure of the drug vial 24.
[0078] [00078] Figure 15C shows another depression downward from the liquid drug transfer assembly 100C towards the drug vial 20 leading to the complete pressure fitting of the drug vial adapter 120 into the drug vial 20 and complete perforation of the closure of the drug vial. drug vial 24 to form a complete drilling hole P. The drug vial adapter sleeve 131 aligns with the following puncture hole P. The rim of the drug vial 26 begins to stimulate the tips of the drug vial leg. 186 out of their respective openings in the tip of the leg of the drug vial 162.
[0079] [00079] Figure 15D shows another depression downward from the liquid drug transfer assembly 100C toward the drug vial 20 to cause the leg tips of the drug vial 186 to leave their respective openings in the leg of the drug vial. drug 162 so that the liquid drug transfer device 180 is free to perform the downward sliding movement with respect to the drug vial adapter 120. The tips of the leg of the drug vial 186 begin to slide downward from the external surfaces 163 of their respective drug-flexing members 161.
[0080] [00080] Figure 15E shows another depression downward from the liquid drug transfer assembly 100C toward the drug vial 20 leading to the leg tips of the drug vial 186 remaining on the edge of the drug vial adapter skirt 129.
[0081] [00081] The liquid drug transfer assembly 100C snaps into the liquid ampoule 30 in a similar way that it fits into the drug ampoule 20. The liquid drug transfer device 180 additionally fits into the adapter of the liquid ampoule 140 to allow for convenient removal of the two components and the empty liquid vial 30 after forming the liquid drug contents in the drug vial 20.
[0082] [00082] Figure 15F shows the operation of the pressure fitting arrangement 190, namely, the pressure members 191 engaging the flange 176 of the tubular member 174.
[0083] [00083] Figures 16A to 16G show the use of the 100C liquid drug transfer assembly for reconstitution of the liquid drug and administration as follows:
[0084] [00084] Figure 16A shows the liquid drug transfer assembly 100C in its initial ready-to-use state for snapping into the drug vial 20 by depressing downward from the previous 100 towards the last 20.
[0085] [00085] Figure 16B shows the downward depression of the liquid drug transfer assembly 100C toward the drug vial 20 causing the liquid drug transfer device 180 to stimulate the drug vial adapter 120 to fit down in the drug vial 20 and the drug vial perforating the member 152 to pierce the closure of the drug vial 24 and the adapter sleeve of the drug vial 131 to align the puncture hole P. Also, the downward movement of the device liquid drug transfer 180 causes the tips of the drug vial leg 186 to be stimulated out of the drug vial adapter 120 and remain on the edge of the drug vial adapter skirt 129.
[0086] [00086] Figure 16C shows the inversion of the assembly of figure 6B to fit by pressure in the liquid ampoule 30.
[0087] [00087] Figure 16D shows the downward depression of the liquid drug transfer assembly 100C toward the drug vial 30 causing the liquid drug transfer device 180 to stimulate the liquid vial adapter 140 downward to fit in the liquid ampoule 30 and in the liquid ampoule that pierces the member 153 to pierce the closure of the liquid ampoule 24. In addition, the downward movement of the liquid drug transfer device 180 causes the tips of the leg of the liquid ampoule 187 to be stimulated out of the liquid ampoule adapter 140 and remain on the edge of the liquid ampoule adapter skirt 148. The downward movement also causes the pressure locking arrangement 190 to operate between the liquid drug transfer device 180 and the liquid drug adapter 140.
[0088] [00088] Figure 16E shows the inversion of the assembly of Figure 16D to allow the transfer of gravitational liquid from the liquid vial 30 to the drug vial 20 to form LD liquid drug contents in the drug vial 20 and ventilation of the drug vial 20 to the liquid ampoule 30. A user can gently shake the assembly of the inverted figure 16D to facilitate the reconstitution or dilution of the LD liquid drug contents.
[0089] [00089] Figure 16F shows the drug vial adapter 120 mounted on drug vial 20 containing liquid drug LD contents after removal of the liquid drug transfer device 180 together with the liquid drug adapter 140 and its liquid vial. empty prey 30.
[0090] [00090] Figure 16G shows the use of needle-free syringe 10 to aspirate LD liquid drug contents from drug ampoule 20 for administration purposes.
[0091] [00091] While the invention has been described with respect to a limited number of modalities, it will be appreciated that many variations, modifications and other applications of the invention can be made within the scope of the appended claims.

权利要求:
Claims (12)
[0001]
Liquid drug transfer assembly (100A; 100B; 100C) for use with a drug vial (20) including a drug vial bottle (21) containing a drug component (27) and having a drug vial opening ( 23) stopped by a closure of the drug vial (24), the liquid drug transfer assembly (100A; 100B; 100C) comprises: (a) a puncture member of the drug vial closure (110; 152) with a puncture tip of the drug vial closure (112; 154) to pierce the closure of the drug vial; and (b) a drug vial adapter (120, 160) having a longitudinal axis of the drug vial adapter (21) and including a drug vial adapter skirt (122) having an upper surface of the drug vial adapter (123) transversely directed formed with a vertical port of the drug vial adapter (124), a part of the drug vial adapter body (128) to comfortably receive the opening of the drug vial (23) and a remote margin of the exit the drug vial adapter (123) from said upper surface of the drug vial adapter, and a sleeve from the drug vial adapter (131); characterized by the fact that the sleeve of the drug vial adapter (131) is downwards depending on said upper surface of the drug vial adapter (123) opposite to said vertical port of the drug vial adapter (124) and in communication fluid with it, said drug vial adapter (120, 160) being slidably arranged on said drug vial closure puncture member (110; 152) so that said drug vial closure puncture tip (112; 154) project beyond said drug ampoule adapter sleeve (131), the arrangement being so that in the assembly the liquid drug transfer assembly in the drug vial (20), said puncture member of the drug vial closure (110; 152) punctures the closure of the drug vial to form a hole complete piercing device and said drug vial adapter sleeve (131) aligns with said puncture hole where, upon removal of said puncture member from the closure of the drug vial (110, 152) of said puncture hole, said drug ampoule adapter sleeve (131) prevents the closure of the drug ampoule (110) thereby sealing allowing fluid communication between said drug ampoule adapter port and the drug ampoule bottle.
[0002]
Assembly according to claim 1, characterized by the fact that said exit of the drug vial adapter (122), said port of the drug vial adapter (124) and said sleeve of the drug vial adapter ( 131) are formed as a single molded plastic injection unit of the same plastic material.
[0003]
Assembly according to claim 1, characterized by the fact that said adapter sleeve of the drug vial (131) is mounted on said skirt of the adapter of the drug vial (122) and is formed from a different material from this .
[0004]
Assembly according to any one of claims 1 to 3, characterized in that said puncture member of the closure of the drug vial (110; 152) includes a liquid drug access port (114) and a longitudinal lumen ( 116) to allow fluid communication access to the drug vial bottle (21) in said puncture of the drug vial closure (24).
[0005]
Assembly according to claim 4, characterized in that the puncture member of the closure of the drug vial (110; 152) includes an in-line filter (117).
[0006]
Assembly according to any one of claims 1 to 3, characterized in that it is for additional use with a liquid ampoule (30) including a liquid ampoule bottle (31) containing a liquid component (37) and having an opening of the liquid ampoule (33) stopped by a closure of the liquid ampoule (34), the liquid component directed to add to the drug component (27) to form the liquid drug contents, wherein said puncture member of the drug vial closure (110; 152) is formed as a double lumen linear transfer clip with double end (151) integrally formed with a liquid vial adapter (140) including a skirt of the liquid ampoule adapter (142) having an upper surface of the transversely directed liquid ampoule adapter (143) and a part of the liquid ampoule adapter body (147) to comfortably receive the opening of the liquid ampoule (33) in him, said double lumen linear transfer clip with double end including a puncture member of the liquid ampoule closure (153) opposite said said puncture member of the drug ampoule closure (152), said puncture member of the closure of the drug vial liquid ampoule having a puncture tip of the liquid ampoule closure (156) to pierce the closure of the liquid ampoule in the assembly of the liquid ampoule adapter in the liquid ampoule thus allowing simultaneous gravitational flow of the liquid component of the liquid ampoule to the drug vial and air flow from the drug vial to the liquid vial in the formation of a vertical assembly of an upper liquid vial and a lower liquid vial to form the liquid drug contents (100A; 100B; 100C) in the vial drug (20) for administration purposes in removing the liquid ampoule adapter from the drug ampoule adapter (120,160).
[0007]
Assembly according to any one of claims 1 to 3, characterized in that it is for additional use with a liquid ampoule (30) including a liquid ampoule bottle (31) containing a liquid component (37) and having an opening of the liquid ampoule (33) stopped by a closure of the liquid ampoule (34), the liquid component directed to add to the drug component (27) to form liquid drug contents, wherein said puncture member of the drug ampoule closure (152) is formed as an end of a double lumen double transfer linear clamp having a longitudinal axis and including (i) a directed puncture member of the opposed liquid ampoule closure (153) with a puncture tip of the liquid ampoule closure (156) to pierce the closure of the liquid ampoule, (ii) a directionally spaced ring (182) transversely rigidly mounted on said linear transfer clamp, (iii) at least two legs of the drug vial (183) directed longitudinally mounted on said spacing ring and extending codirectionally and spaced from said puncture member of the closure of the drug vial (110), at least two said legs of the drug vial that terminate at the tips of the leg of the drug vial (186) coextensive and inward projecting on said puncture tip of the closure of the drug vial (110), (iv) at least two longitudinally directed liquid ampoule legs (184) mounted on said spacing ring and extending codirectionally and spaced from said puncture member of the liquid ampoule closure, at least two said legs of the liquid ampoule that end at the tips of the leg of the liquid ampoule (187) coextensive and inwardly projecting towards said puncture tip of the closure of the liquid ampoule, said drug vial adapter (160) being slidably mounted on said puncture member of the drug vial closure (152) with said top surface of the drug vial adapter (123) towards said spacing ring (123) and said remote margin (129) of the drug vial adapter skirt, said skirt of the drug vial adapter (122) having the openings of the leg of the drug vial (162) to initially receive said leg tips of the drug vial (186) to initially space said adapter of the vial of the vial drug from said spacing ring so that said skirt margin of the drug vial adapter is far from said spacing ring than from said drug vial piercing tip where, in the slide of said drug vial adapter ( 120) towards said spacing ring, said skirt of the drug vial adapter (122) mounts in the opening of the drug vial (23) to close the opening of the drug vial (23) in said part of the adapter body of the drug vial (120), said puncture member of the drug vial closure (152) perforates the closure of the drug vial (24) for fluid communication with the drug vial bottle (21) and said tips of the leg of the drug vial slide through said skirt of the vial adapter drug (122) towards said skirt edge of the drug vial adapter (122); and (c) a liquid ampoule adapter (170) including a liquid ampoule skirt adapter (142) having an upper surface of the transversely directed liquid ampoule adapter formed with a part of the liquid ampoule adapter body (147 ) to comfortably receive the opening of the liquid ampoule (33) and a skirt edge of the liquid ampoule adapter (148), said liquid ampoule adapter (170) being slidably disposed on said puncture member of the liquid ampoule closure (153) with said upper surface of the liquid ampoule adapter towards said spacing ring and said margin of the get off the adapter of his remote liquid ampoule, said liquid ampoule adapter skirt having openings of the liquid ampoule leg (172) to initially receive said liquid ampoule leg tips (187) to initially space said liquid ampoule adapter from said ring of spacing so that said skirt margin of the liquid ampoule adapter is farther from said spacing ring than from said puncture tip of the liquid ampoule closure where, in the slide of said liquid ampoule adapter towards the said spacing ring, said liquid ampoule adapter skirt (142) mounts in the liquid ampoule opening to close the liquid ampoule opening (33) in said body part of the liquid ampoule adapter, said member puncture of the liquid ampoule closure (153) pierces the closure of the liquid ampoule (34) for fluid communication with the liquid ampoule bottle (31) and said tips of the liquid ampoule leg slide through said adapter skirt gives liquid ampoule towards said skirt edge of the liquid ampoule adapter.
[0008]
Assembly according to claim 7, characterized in that said liquid drug transfer device (180) and said liquid ampoule adapter (170) have a pressure fitting arrangement (190) for mechanically securing the said liquid drug transfer device to said liquid ampoule adapter in the assembly of said liquid ampoule adapter in the liquid ampoule.
[0009]
Assembly according to claim 8 characterized by the fact that said pressure fitting arrangement (190) is constituted by said adapter port of the liquid ampoule having a longitudinally directed tubular member (174) towards said spacing ring (182) and said spacing ring having at least one pressure member (191) to press fit into said tubular member.
[0010]
Assembly according to any one of claims 7 to 9, characterized in that said skirt edge of the drug vial adapter (129) is externally enlarged with respect to said body part of the drug vial adapter (128 ) and includes flat outer surfaces (163) to facilitate said sliding of said tips of the drug vial leg (186) towards said skirt edge of the drug vial adapter (129).
[0011]
Assembly according to any one of claims 7 to 10, characterized in that the said skirt margin of the liquid ampoule adapter (148) is externally enlarged with respect to said body part of the liquid ampoule adapter (147) ) and includes flat outer surfaces (173) to facilitate the sliding of said tips of the liquid ampoule leg (187) towards said skirt edge of the liquid ampoule adapter (148).
[0012]
Assembly according to any one of claims 7 to 11, characterized in that the liquid drug transfer assembly (100C) is packaged in an alveolar package and each leg of the liquid ampoule (184) has at least one protrusion of the ampoule of the outwardly directed liquid leg (188) for rolling against an internal surface of said honeycomb package.

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同族专利:

公开号 | 公开日

EP2680806B1|2015-04-15|

CN103458850A|2013-12-18|

IL212420D0|2011-06-30|

CN103458850B|2015-04-29|

US20140020793A1|2014-01-23|

DK2680806T3|2015-06-29|

IL228452D0|2013-12-31|

WO2012143921A1|2012-10-26|

EP2680806A1|2014-01-08|

US8752598B2|2014-06-17|

JP2014514114A|2014-06-19|

JP5681834B2|2015-03-11|

IL228452A|2018-02-28|

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法律状态:
2018-12-18| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|

2020-03-17| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|

2020-08-18| B06A| Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law|

2020-12-01| B09A| Decision: intention to grant|

2021-02-17| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/04/2012, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

IL21242011A|IL212420D0|2011-04-17|2011-04-17|Liquid drug transfer assembly|

IL212420|2011-04-17|

PCT/IL2012/000164|WO2012143921A1|2011-04-17|2012-04-17|Liquid drug transfer assembly|

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